Dr. Chesler's research emphasizes the integration of genomic and phenomic resources. Her current research emphasizes ontological discovery from the extraction of sets of genes and phenotypes from large empirical data sets. These efforts include the production and characterization of the Collaborative Cross and studies involving the BXD Recombinant Inbred Lines. Dr. Chesler and colleagues integrate statistical and combinatoric approaches to systems genetic analysis. Her previous research explored two important issues pertaining to the widespread use of standard inbred mouse strains for this purpose. She has previously established several algorithmic, statistical and population based hurdles to the use of common inbred strains as a genetic mapping panel (Chesler et al 2001, Mhyre et al, 2005). She has also examined issues in combining data from genetic projects across labs, extracting specific factors responsible for genetic interactions with the laboratory environment using a computational analysis of a large data archive featuring observations of a single behavioral measurement acquired thousands of times in the laboratory of one investigator (Chesler et al, 2002a,b).

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